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ritonavir will raise the amount or effect of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.chloramphenicol will enhance the amount or outcome of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.The sq. root of 2 and approximations by convergents of ongoing fract